Publications
Below you can find a list of our published research.
Below you can find a list of our published research.
140 results
Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland, 30 5 2024 Dissecting the surgeon's personality: cross-cultural comparisons in Western Europe. Sier VQ, Bisset CN, Tesselaar DAJ, Schmitz RF, Schepers A, Moug SJ, van der Vorst JR, SUPER and Plato Project Collaborators
Aim: The surgeon's personality contributes to variation in surgical decision-making. Previous work on surgeon personality has largely been reserved to Anglo-Saxon studies, with limited international comparisons. In this work we built upon recent work on gastrointestinal surgeon personality and aimed to detect international variations. Method: Gastrointestinal surgeons from the UK and the Netherlands were invited to participate in validated personality assessments (44-item, 60-item Big Five... Abstract
Annals of vascular surgery, 12 2 2024, Pages S0890-5096(24)00174-2 Towards uniform case-identification criteria in observational studies on peripheral arterial disease: A scoping review. Keekstra N, Biemond M, van Schaik J, Schepers A, Hamming JF, van der Vorst JR, Lindeman JHN
Objective: The diagnosis peripheral arterial disease (PAD) is commonly applied for symptoms related to atherosclerotic obstructions in the lower extremity, though its clinical manifestations range from an abnormal Ankle Brachial Index to critical limb ischemia. Subsequently, management and prognosis of PAD vary widely with the disease stage. A critical aspect is how this variation is addressed in administrative databases-based studies that rely on diagnosis codes for case identification. The obj... Abstract
Journal of translational medicine, Volume 22, Issue 1, 3 1 2024, Pages 234 CRISPR/Cas9-edited ROS1 + non-small cell lung cancer cell lines highlight differential drug sensitivity in 2D vs 3D cultures while reflecting established resistance profiles. Terrones M, Deben C, Rodrigues-Fortes F, Schepers A, de Beeck KO, Van Camp G, Vandeweyer G
Introduction: The study of resistance-causing mutations in oncogene-driven tumors is fundamental to guide clinical decisions. Several point mutations affecting the ROS1 kinase domain have been identified in the clinical setting, but their impact requires further exploration, particularly in improved pre-clinical models. Given the scarcity of solid pre-clinical models to approach rare cancer subtypes like ROS1 + NSCLC, CRISPR/Cas9 technology allows the introduction of mutations in patient-derived... Abstract
Cell reports. Medicine, Volume 5, Issue 3, 1 1 2024, Pages 101471 Targeting of vulnerabilities of drug-tolerant persisters identified through functional genetics delays tumor relapse. Chen M, Mainardi S, Lieftink C, Velds A, de Rink I, Yang C, Kuiken HJ, Morris B, Edwards F, Jochems F, van Tellingen O, Boeije M, Proost N, Jansen RA, Qin S, Jin H, Koen van der Mijn JC, Schepers A, Venkatesan S, Qin W, Beijersbergen RL, Wang L, Bernards R
Drug-tolerant persisters (DTPs) are a rare subpopulation of cells within a tumor that can survive therapy through nongenetic adaptive mechanisms to develop relapse and repopulate the tumor following drug withdrawal. Using a cancer cell line with an engineered suicide switch to kill proliferating cells, we perform both genetic screens and compound screens to identify the inhibition of bromodomain and extraterminal domain (BET) proteins as a selective vulnerability of DTPs. BET inhibitors are espe... Abstract
International journal of surgery (London, England), Volume 109, Issue 12, 1 1 2023, Pages 4057-4061 Predictors for postoperative cranial nerve complications in carotid body tumor resection: a retrospective cohort study. Alimohamad H, Yilmaz D, Marang-van de Mheen PJ, Jansen J, Hamming JF, Schepers A
Introduction: Carotid body tumors (CBTs) are slow-growing benign tumors. Therefore, surgical resection is considered in case of tumor growth. The timing of surgery is of the utmost importance as the risk of iatrogenic surgical complications increases when resecting larger tumors, whereas on the other hand, resections for asymptomatic small CBT should be prevented. The primary aim of this study was to identify which tumor size or dimension is most accurate to predict nerve injury in patients unde... Abstract
Journal of vascular surgery, Volume 79, Issue 2, 31 5 2023, Pages 405-411 Diagnostic accuracy of the maximal systolic acceleration to detect peripheral arterial disease. Willems SA, Dolfing SG, van Wissen RC, van der Vorst JR, van Schaik J, Schepers A, Hamming JF, Brouwers JJWM
Background: Diagnosing peripheral arterial disease (PAD) can be challenging owing to medial arterial calcification (MAC) in patients with diabetes mellitus (DM) and chronic kidney disease (CKD). Current bedside tests, such as the ankle-brachial index and toe-brachial index, are often insufficient. The maximal systolic acceleration (ACCmax) is a velocimetric Doppler-derived parameter and could be a new promising test in the diagnostic workup of these patients. The primary aim of this study was to... Abstract
International journal of molecular sciences, Volume 24, Issue 18, 7 1 2023, Pages 13822 Exploring the Effects of Human Bone Marrow-Derived Mononuclear Cells on Angiogenesis In Vitro. Peeters JAHM, Peters HAB, Videler AJ, Hamming JF, Schepers A, Quax PHA
Cell therapies involving the administration of bone marrow-derived mononuclear cells (BM-MNCs) for patients with chronic limb-threatening ischemia (CLTI) have shown promise; however, their overall effectiveness lacks evidence, and the exact mechanism of action remains unclear. In this study, we examined the angiogenic effects of well-controlled human bone marrow cell isolates on endothelial cells. The responses of endothelial cell proliferation, migration, tube formation, and aortic ring sprouti... Abstract
The British journal of surgery, Volume 110, Issue 10, 1 1 2023, Pages 1271-1275 Surgical team dynamics in a reflective team meeting to improve quality of care: qualitative analysis of a shared mental model. Verhagen MJ, de Vos MS, van Schaik J, van der Vorst JR, Schepers A, Marang-van de Mheen PJ, Hamming JF
Cited 1 times since 2023 (1.4 per year) source: EuropePMC
Journal of vascular surgery cases and innovative techniques, Volume 9, Issue 4, 15 3 2023, Pages 101297 Therapeutic management of in-stent thrombosis after thoracic endovascular aortic repair for blunt thoracic aortic injury in a coronavirus disease 2019 patient. van Rijn K, Schepers A, van der Meer RW, van Rijswijk CSP, van Schaik J, van der Vorst JR
A 27-year-old man underwent thoracic endovascular aortic repair for blunt thoracic aortic injury. Fourteen months later, he presented with intermittent paraplegia, congestive heart failure, and a decline of kidney function as a result of high-grade aortic stenosis caused by in-stent thrombosis. He had a concurrent infection with coronavirus disease 2019. The patient was successfully treated using axillofemoral bypass, followed by stent relining 2 weeks later. The possible risk factors and the op... Abstract
Cited 2 times since 2023 (2.7 per year) source: EuropePMC
Endocrine-related cancer, Volume 30, Issue 9, 3 1 2023, Pages e230047 A clinically applicable molecular classification of oncocytic cell thyroid nodules. de Koster EJ, Corver WE, de Geus-Oei LF, Oyen WJG, Ruano D, Schepers A, Snel M, van Wezel T, Vriens D, Morreau H
Whole chromosome instability with near-whole genome haploidization (GH) and subsequent endoreduplication is considered a main genomic driver in the tumorigenesis of oncocytic cell thyroid neoplasms (OCN). These copy number alterations (CNA) occur less frequently in oncocytic thyroid adenoma (OA) than in oncocytic carcinoma (OCA), suggesting a continuous process. The current study described the CNA patterns in a cohort of 30 benign and malignant OCN, observed using a next-generation sequencing (N... Abstract
Cited 2 times since 2023 (2.4 per year) source: EuropePMC
Acta neuropathologica communications, Volume 11, Issue 1, 11 2 2023, Pages 112 Targeting the glycine-rich domain of TDP-43 with antibodies prevents its aggregation in vitro and reduces neurofilament levels in vivo. Riemenschneider H, Simonetti F, Sheth U, Katona E, Roth S, Hutten S, Farny D, Michaelsen M, Nuscher B, Schmidt MK, Flatley A, Schepers A, Gruijs da Silva LA, Zhou Q, Klopstock T, Liesz A, Arzberger T, Herms J, Feederle R, Gendron TF, Dormann D, Edbauer D
Cytoplasmic aggregation and concomitant nuclear clearance of the RNA-binding protein TDP-43 are found in ~ 90% of cases of amyotrophic lateral sclerosis and ~ 45% of patients living with frontotemporal lobar degeneration, but no disease-modifying therapy is available. Antibody therapy targeting other aggregating proteins associated with neurodegenerative disorders has shown beneficial effects in animal models and clinical trials. The most effective epitopes for safe antibody therapy targeting TD... Abstract
Clinical epigenetics, Volume 15, Issue 1, 6 1 2023, Pages 111 Epigenome-wide methylation analysis of colorectal carcinoma, adenoma and normal tissue reveals novel biomarkers addressing unmet clinical needs. Janssens K, Neefs I, Ibrahim J, Schepers A, Pauwels P, Peeters M, Van Camp G, Op de Beeck K
Background: Biomarker discovery in colorectal cancer has mostly focused on methylation patterns in normal and colorectal tumor tissue, but adenomas remain understudied. Therefore, we performed the first epigenome-wide study to profile methylation of all three tissue types combined and to identify discriminatory biomarkers. Results: Public methylation array data (Illumina EPIC and 450K) were collected from a total of 1 892 colorectal samples. Pairwise differential methylation analyses between tis... Abstract
The British journal of surgery, Volume 110, Issue 8, 1 1 2023, Pages 991-992 Future surgeon: bridging the intergenerational gap. Huizing F, Sier VQ, Tresfon JAS, van der Vorst JR, Liem RSL, Schmitz RF, Schepers A, Houwert RM, Vriens MR, Snijders HS, Blok JJ
Angiology, 26 4 2023, Pages 33197231186096 Near-Infrared Fluorescence Imaging With Indocyanine Green to Predict Clinical Outcome After Revascularization in Lower Extremity Arterial Disease. Tange FP, van den Hoven P, van Schaik J, Schepers A, van der Bogt KEA, van Rijswijk CSP, Putter H, Vahrmeijer AL, Hamming JF, van der Vorst JR
Contemporary quality control methods are often insufficient in predicting clinical outcomes after revascularization in lower extremity arterial disease (LEAD) patients. This study evaluates the potential of near-infrared fluorescence imaging with indocyanine green to predict the clinical outcome following revascularization. Near-infrared fluorescence imaging was performed before and within 5 days following the revascularization procedure. Clinical improvement was defined as substantial improveme... Abstract
Cited 1 times since 2023 (0.8 per year) source: EuropePMC
Annals of vascular surgery, Volume 93, 13 2 2023, Pages 283-290 Evaluation of the Angiosome Concept Using Near-Infrared Fluorescence Imaging with Indocyanine Green. Tange FP, Ferrari BR, van den Hoven P, van Schaik J, Schepers A, van Rijswijk CSP, van der Meer RW, Putter H, Vahrmeijer AL, Hamming JF, van der Vorst JR
Background: The angiosome concept is defined as the anatomical territory of a source artery within all tissue layers. When applying this theory in vascular surgery, direct revascularization (DR) is preferred to achieve increased blood flow toward the targeted angiosome of the foot in patients with lower extremity arterial disease (LEAD). This study evaluates the applicability of the angiosome concept using quantified near-infrared (NIR) fluorescence imaging with indocyanine green (ICG). Methods:... Abstract
Cited 1 times since 2022 (0.7 per year) source: EuropePMC
Langenbeck's archives of surgery, Volume 407, Issue 8, 1 1 2022, Pages 3909 Correction to: Outcomes of parathyroidectomy versus calcimimetics for secondary hyperparathyroidism and kidney transplantation: a propensity-matched analysis. Koh EY, van der Plas WY, Dulfer RR, Pol RA, Kruijff S, Rotmans JI, Appelman-Dijkstra N, Schepers A, de Borst MH, Hoorn EJ, van Ginhoven TM, Nieveen van Dijkum EJM, Vogt L, Engelsman AF, Dutch Hyperparathyroidism Study Group
Cited 7 times since 2022 (4.8 per year) source: EuropePMC
Nature cancer, Volume 3, Issue 11, 22 4 2022, Pages 1284-1299 cFLIP suppression and DR5 activation sensitize senescent cancer cells to senolysis. Wang L, Jin H, Jochems F, Wang S, Lieftink C, Martinez IM, De Conti G, Edwards F, de Oliveira RL, Schepers A, Zhou Y, Zheng J, Wu W, Zheng X, Yuan S, Ling J, Jastrzebski K, Santos Dias MD, Song JY, Celie PNH, Yagita H, Yao M, Zhou W, Beijersbergen RL, Qin W, Bernards R
Senolytics, drugs that kill senescent cells, have been proposed to improve the response to pro-senescence cancer therapies; however, this remains challenging due to a lack of broadly acting senolytic drugs. Using CRISPR/Cas9-based genetic screens in different senescent cancer cell models, we identify loss of the death receptor inhibitor cFLIP as a common vulnerability of senescent cancer cells. Senescent cells are primed for apoptotic death by NF-κB-mediated upregulation of death receptor 5 (DR5... Abstract
Cited 1 times since 2022 (0.6 per year) source: EuropePMC
PloS one, Volume 17, Issue 9, 30 5 2022, Pages e0274478 Long-term in vitro 2D-culture of SDHB and SDHD-related human paragangliomas and pheochromocytomas. Bayley JP, Rebel HG, Scheurwater K, Duesman D, Zhang J, Schiavi F, Korpershoek E, Jansen JC, Schepers A, Devilee P
The neuroendocrine tumours paraganglioma and pheochromocytoma (PPGLs) are commonly associated with succinate dehydrogenase (SDH) gene variants, but no human SDH-related PPGL-derived cell line has been developed to date. The aim of this study was to systematically explore practical issues related to the classical 2D-culture of SDH-related human paragangliomas and pheochromocytomas, with the ultimate goal of identifying a viable tumour-derived cell line. PPGL tumour tissue/cells (chromaffin cells)... Abstract
Cited 6 times since 2022 (3.6 per year) source: EuropePMC
PloS one, Volume 17, Issue 9, 6 1 2022, Pages e0273182 Indisulam synergizes with palbociclib to induce senescence through inhibition of CDK2 kinase activity. Pogacar Z, Johnson JL, Krenning L, De Conti G, Jochems F, Lieftink C, Velds A, Wardak L, Groot K, Schepers A, Wang L, Song JY, van de Ven M, van Tellingen O, Medema RH, Beijersbergen RL, Bernards R, Leite de Oliveira R
Inducing senescence in cancer cells is emerging as a new therapeutic strategy. In order to find ways to enhance senescence induction by palbociclib, a CDK4/6 inhibitor approved for treatment of metastatic breast cancer, we performed functional genetic screens in palbociclib-resistant cells. Using this approach, we found that loss of CDK2 results in strong senescence induction in palbociclib-treated cells. Treatment with the CDK2 inhibitor indisulam, which phenocopies genetic CDK2 inactivation, l... Abstract
Surgery, Volume 172, Issue 5, 3 1 2022, Pages 1358-1363 The big five: Studying the surgical personality. Sier VQ, Schmitz RF, Putter H, Schepers A, van der Vorst JR
Background: The challenging nature of performing surgery on a personal and professional level demands specific characteristics. Personality traits play an important role in the nature and behavior of humans, which are studied using the five-factor model. Therefore, we investigated the personality of 3 surgical generations. Methods: Three distinct surgical populations were approached. The Dutch Big Five Inventory-2 was sent out online to 126 surgical residents (response: n = 69) and 104 surgeons... Abstract